From our point of view, periarteritis nodosa is a pathocomplex-induced disease. In this case, the pathocomplexes attack vessels of various organs, including the heart, brain and muscles, triggering their infractions of various severities. As they circulate in the bloodstream and attract blood cells and particularly B-lymphocytes, plasmocytes, thrombocytes, erythrocytes and protein components, the pathocomplexes form gigantic aggregates that subsequently occlude various blood vessels, and especially capillaries of organs, resulting in thrombotic strokes. That means that the blood flow of the surrounding tissues supplied by the affected blood vessels is damaged. As a result, the organ tissues of this region die out and subsequently, become replaced by connective tissue (focus of sclerosis). This is exactly what is ultimately revealed by magnetic resonance imaging. A symptom complex characteristic for the given functional area develops depending on which organ has the lesion focus.
Treatment of periarteritis nodosa on the basis of pathocomplex process completely eliminates the source of this disease in the blood. This means that the progress of this disease becomes suspended and the recently developed thromboses resolve. However, recovering pockets of multiple sclerosis (connective tissue) and the proceeding functional disorders is difficult.