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The Pathocomplex Process

 

When Thomas Newcomen, an English smith, created the first steam engine in 1712, he never guessed that this event would bring our mankind to such a dimensional deadlock at the end of the 20th century. The industrial revolution and the dramatic process of urbanization following it were the starting points of evolutional, biological and adaptive changes that brought our human physiology to its present state.

In the second half of the 18th century, as a result of industrial and urban developments, our mankind makes a sharp turn towards urbanization, estranging from its natural conditions in the meanwhile. The human environment undergoes tremendous changes. Based on fundamental changes of the human life conditions, biological and evolutionary reorganizations in its body and systems emerge.

Before that moment, our mankind lived on Earth in relatively constant conditions for over 15–20 thousand years. In relationship to nature, no chemicals for increasing yields of agricultural products were used and ultraviolet irradiation had penetrated the ground with less intensity. Owing to these factors, a very limited number of antigens would penetrate the body. As a result, the blood retained its more or less ideal flow characteristics.

Human B-lymphocytes
Human B-lymphocytes

Humanity’s sharp turn towards urbanization in the second half of the 18th century, the use of technology and various chemicals in our daily lives has contributed to the sudden creation of a severe load on our immune system. Within a short period of time, thousand varieties of new antigens, including technical, chemical, radiological and endogenous antigens as well as antigens arising from stressful situations came about and attacked the human body. Until that time, all of the body’s defense reactions were balanced and evenly divided out between all of blood’s leukocytes. Every cell carried out its fight against rarely attacking antigens with its specific mechanisms. Gradually, with the advent of antigens of high molecular weight, including biological antigens, the body’s defensive function shifted to primarily lymphocytes and B-lymphocytes, in particular. Protein or humoral immunity emerged to the first place.

Until that time, the protein molecules i.e. immunoglobulins G, E, D, A and M, synthesized by В-lymphocytes, entered bloodstream and hunted for foreign substances attaching themselves to these substances with their variable ends. These complexes, i.e. protein complexes with antigens, were destroyed by different mechanisms with the help of different blood cells from the group of lymphocytes, including monocytes, macrophages, granulocytes and others.

Due to the changes in the defensive mechanism of leukocytes that have occurred over the course of the last centuries, the defensive protein molecules remain fixed on the surface on B-lymphocytes in most cases and hunt for foreign substances whilst circulating in the blood flow in such form. At foreign substance’s penetration to the body, B-lymphocytes surround it from all directions and bind to it, fixating with variable ends of their surface proteins, i.e. immunoglobulins. This is how immune complexes are formed. Their purpose is the eradication of antigens and in particular, antigens of high molecular weight.

Following antigen destruction, these immune complexes must disassemble wherein B-lymphocyte cells are released one by one and thus continue on performing their defensive function. This occurs when the number of B-lymphocytes and the number of antigens have a logical relationship. This means that following their release from one of the complexes, B-lymphocytes must be able to circulate some time freely in the circulatory system. If the number of antigens, particularly antigens of protein origin, exceeds the number of B-lymphocytes, then these cells are not able to freely circulate in the blood upon disassociation, but instead are forced to immediately proceed towards eliminating another antigen, thus forming a new complex. Consequently, В-lymphocytes are incapable of swimming freely in the blood flow and they are continuously or most of their time of existence and circulation in the bloodstream associated in complexes.

The function of disbanding immune complexes, i.e. releasing B-lymphocytes from these complexes, is carried by several chemical substances that must be constantly synthesized into the blood serum. With an endless increase of antigens in the modern world, and particularly antigens of high molecular weights, on the one hand and a decrease in synthesis of substances required for the release of B-lymphocytes as a result of biological changes that occurred in the human body over the past centuries on the other hand, B-cells have less and less chance to circulate in the bloodstream without being associated to complexes. Thus, they are almost continuously encompassed in these complexes.

Upon a change of any biological being’s environmental conditions, evolutional reorganizations corresponding to the changes in environment must occur in his body. This is a natural adaptive response of the body.

Following the sharp turn towards urbanization resulting from the Industrial Revolution of the 18th century and an abrupt alienation from natural conditions and constant lifestyle that has lasted for nearly 15 thousand years, the human body has also undergone drastic biological, evolutional and adaptive reorganizations. A reduction of synthesis of those substances that are required for the disbandment of immune complexes and release of B-lymphocytes is the very result of these changes.

On the other hand, the spurt of various antigens in the human body has triggered a deadlock in the immune system. As a result of the occurred changes, instead of floating freely in the bloodstream, B-lymphocytes are constantly encompassed in one of the immune complexes and consequently, they have less and less chances of moving out to their free form. Pathological immune complexes emerge for the first time in the biological life (pathocomplexes). Our humanity faces a new medical phenomenon called the pathocomplex process.

With their large size, the associated immune complexes are not intended for circulation in the human circulatory system and for this reason they clog one blood vessel after another during their circulation. These same pathological complexes settle on the serous membranes of various organs, causing their inflammatory process. A completely new symptom complex of systemic pathologies develops.

On the basis of emerged accumulating conditions, in 1835, a French physician Bouillaud, discovered for the first time a disease that had no similarity to the disease described in due time by Galen. Bouillaud called the disease rheumatism in his honor, although 18th century’s medicine was much more modern than the medicine of Galen’s times for the theory of four circulating fluids to be accepted as the basis of explaining the etiology of the given disease. What Bouillaud described was already a clinical symptom complex of a new group of diseases that were one after another opened by 1920s.

A short time after the French physician Bouillaud had described the symptoms of rheumatism; in 1836, Bright detected a disease of kidneys – glomerulonephritis; in 1847, Gintrak – the disease of scleroderma. Then, in 1891, Unverricht and Wagner had described the disease of dermatomyositis; in the period of 1894 to 1903, Crocker and Williams described the disease of lupus erythematosus and in 1926, periarteritis was first detected and described by Graber. As you can see, all the diseases of this group were detected and described after 1835.

Thus, pathological immune complexes have created two problems for the humanity of the following centuries. The first problem is the emergence of diseases caused by the sedimentation of pathocomplex networks in tissues and blood vessels of the human body with subsequent damage of highly specialized tissue of the given organs. The second problem is the emergence of immunodeficiency due to the entrapment of leukocytes in immune pathological complexes, especially B-lymphocytes, the key effectors of body defenses. As a result of B-lymphocytes’ entrapment in the pathocomplex network as well as their inability to be disassociated due to insufficient synthesis of essential substances, the human immune system partially and later completely paralyzes  a partial or complete immunodeficiency emerges.

In the course of its evolution in the 1930s, the pathocomplex process generates a new group of diseases that contrary to popular pseudo-scientific claims, our humanity has never encountered before. These are cardiovascular diseases, manifested as hypertension, ischemic heart disease, arrhythmias, heart attacks and strokes which have now consolidated their position at the leading factors of global morbidity and mortality.

The growing incidence of pathocomplex process, reaching its peak by the 1980s, has resulted in a complete immune deficiency. Suddenly, a new condition for the human body appears and takes our humanity by surprise much like the onset of cardiovascular pathologies in the 1930s.

With the nomination of the pathocomplex process theory, many diseases that to this day had no scientific explanations satisfying scientific requirements can be successfully cured. New solutions emerged for many still unresolved problems of the cardiovascular system, including ischemic heart disease and arrhythmia of coronary origin, problems of immune system, such as AIDS, as well as systemic pathologies and others.

Mechanism of  formation and disbandment of immune complexes
Mechanism of formation and disbandment of immune complexes
Pathocomplex process
Pathocomplex process